Inflammation Research
Yuan, Jing; Zou, Rougrong; Zeng, Lijiao; Kou, Shanglong; Lan, Jianfeng; Li, Xiaohe; Liang, Yanhua; Ding, Xiaoyan; Tan, Guoyu; Tang, Shenghong; Liu, Lei; Liu, Yingxia; Pan, Yanchao; Wang, Zhaoqin
Abstract
Objective: This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020.
Methods: The clinical and laboratory fndings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected.
Results: COVID-19 mRNA clearance ratio was identifed signifcantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α+lopinavir/ritonavir or IFN-α+lopinavir/ritonavir+ribavirin.
Conclusions: Therapeutic regimens of IFN-α+lopinavir/ritonavir and IFN-α+lopinavir/ritonavir+ribavirin might be benefcial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection.
Keywords
COVID-19, Clearance ratio, LDH, CK