Journal of Neuroimmunology
Volume 119, Issue 2, 1 October 2001, Pages 175-182
Stanley A. Vinores, Yun Wang, Melissa A. Vinores, Nancy L. Derevjanik, Albert Shi, Diane A. Klein, Barbara Detrick, John J. Hooks
Abstract
Intraocular coronavirus inoculation results in a biphasic retinal disease in susceptible mice (BALB/c) characterized by an acute inflammatory response, followed by retinal degeneration associated with autoimmune reactivity. Resistant mice (CD-1), when similarly inoculated, only develop the early phase of the disease. Blood–retinal barrier (BRB) breakdown occurs in the early phase in both strains, coincident with the onset of inflammation. As the inflammation subsides, the extent of retinal vascular leakage is decreased, indicating that BRB breakdown in experimental coronavirus retinopathy (ECOR) is primarily due to inflammation rather than to retinal cell destruction. Vascular endothelial growth factor (VEGF) is upregulated only in susceptible mice during the secondary (retinal degeneration) phase.
Keywords
Coronavirus, Blood–retinal barrier, Vascular endothelial growth factor, Retinopathy