Pyrimidines

Infectious Without Symptoms

New Scientist
Volume 245, Issue 3275, 28 March 2020, Pages 10-11

Lawton, Graham

Abstract

It is easy to spread the virus without realising you are ill, reports Graham Lawton

WITH more than 380,000 confirmed cases worldwide, one thing is clear about the new coronavirus: it is very good at infecting people. Now studies are starting to reveal just how infectious it is – and when a person with covid-19 is most likely to spread the virus.

Keywords

Epidemiology

You're Only As Young As Your Immune System

New Scientist
Volume 245, Issue 3275, March 2020, Pages 44-48

Lawton, Graham

Introduction

There has never been a more important time to keep your immune system fit and healthy. And as Graham Lawton discovers, there are now ways to keep it younger than you are.

WASH your hands religiously for 20 seconds, sneeze into your elbow, avoid touching your face, stay 1 meter away from all other people and, as a last resort, self-quarantine for a week with only your emergency rations for company. If you want to avoid getting the new coronavirus, all of these are a good idea. But ultimately, one of the most important things standing between you and a deadly bout of COVID-19 is your immune system.

Keywords

Epidemiology



Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

Bioorganic & Medicinal Chemistry Letters
Volume 20, Issue 12, 15 June 2010, Pages 3569-3572

R. Ramajayam, Kian- Pin Tan, Hun- Ge Liu, Po- Huang Liang

Abstract

A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.

Keywords

SARS-CoV, Pyrimidines



Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

Bioorganic & Medicinal Chemistry Letters
Volume 20, Issue 12, 15 June 2010, Pages 3569-3572

R. Ramajayam, Kian-Pin, Tan, Hun-GeLiu, Po-HuangLiang

Abstract

A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.

Keywords

SARS-CoV, Pyrimidines