Book reviews

Dynamics of scientific publications on the MERS-CoV outbreaks in Saudi Arabia

Journal of Infection and Public Health
Volume 10, Issue 6, November–December 2017, Pages 702-710

Ali A. Rabaan, Shamsah H. Al-Ahmed, Ali M.Bazzi, and Jaffar A. Al-Tawfiq

Abstract

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging disease with a relatively high case fatality rate. Most cases have been reported from Saudi Arabia, and the disease epidemic potential is considered to be limited. However, human–human transmission has occurred, usually in the context of healthcare facility-associated outbreaks. The scientific and medical community depends on timely publication of epidemiological information on emerging diseases during outbreaks to appropriately target public health responses. In this review, we considered the academic response to four MERS CoV outbreaks that occurred in Al-Hasa in 2013, Jeddah in 2014 and Riyadh in 2014 and 2015. We analysed 68 relevant epidemiology articles. For articles for which submission dates were available, six articles were submitted during the course of an outbreak. One article was published within a month of the Al-Hasa outbreak, and one each was accepted during the Jeddah and Riyadh outbreaks. MERS-CoV epidemiology articles were cited more frequently than articles on other subjects in the same journal issues. Thus, most epidemiology articles on MERS-CoV were published with no preferential advantage over other articles. Collaboration of the research community and the scientific publishing industry is needed to facilitate timely publication of emerging infectious diseases.

Keywords

Middle East Respiratory Syndrome Coronavirus, Outbreak, Epidemiology, Publication, Saudi Arabia, MERS-CoV

T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV

Antiviral Research
Volume 137, January 2017, Pages 82-92

William J .Liu, Min Zhao,Kefang Liu, Kun Xud, Gary Wong, Wenjie Tan, George F. Gao

Abstract

Over 12 years have elapsed since severe acute respiratory syndrome (SARS) triggered the first global alert for coronavirus infections. Virus transmission in humans was quickly halted by public health measures and human infections of SARS coronavirus (SARS-CoV) have not been observed since. However, other coronaviruses still pose a continuous threat to human health, as exemplified by the recent emergence of Middle East respiratory syndrome (MERS) in humans. The work on SARS-CoV widens our knowledge on the epidemiology, pathophysiology and immunology of coronaviruses and may shed light on MERS coronavirus (MERS-CoV). It has been confirmed that T-cell immunity plays an important role in recovery from SARS-CoV infection. Herein, we summarize T-cell immunological studies of SARS-CoV and discuss the potential cross-reactivity of the SARS-CoV-specific immunity against MERS-CoV, which may provide useful recommendations for the development of broad-spectrum vaccines against coronavirus infections.

Keywords

SARS-CoV, MERS-CoV, Vaccine, T-cell, Epitope, Cross-reactivity